the big difference in my experience is to stay away from multi-strand wire.
I believe that the problem lies in the fact that the thin strands which are bunched up are connected to each other because they are touching but they are subject to false contact throughout the length of the wire, because of oxidization, dirt and other reasons.
in the end, you get the sum of the various contact-distortion caused by each individual strand.
you can hear this on old guitar cables which 'crunch' when you handle them.
solid copper does not have these problems
I have yet to try silver but I probably will.
one very quick way of hearing a difference in imaging when changing wire on speakers is to try ordinary phone wire, or multi strand phone wire..
you can also wire three or four (or more) insulated phone wires in parallel to get a lower impedance.
I've found that it is superior to run-of-the-mill multi-strand 'speaker wire'