There's a balance to be found between ergonomics and acoustics. A person needs to accomplish work in the room every day, and for me, that means having a console of some kind. However, it makes sense to keep it as small as possible, pay attention to the angles for reflections into the listening position, and I've even built acoustic treatments into key spots in the desk. If more space is needed, add low angled racks to the sides. Also it pays to keep the bottom open, instead of everything closed off right down to the floor.
As for screens (video/computer monitors), there are 2 in my space. One is on a small rolling cart off to the side (not pictured). I can move it closer if I'm doing a lot of editing, or leave it out of the way if EQing. The mouse and keyboard are wireless, so I can put those on the main console, or leave them on the cart as desired.
The second screen is in front of the room. We do a lot of concert video, so sometimes it displays the corresponding picture. It can also be switched to display a second computer, or to be a second monitor for the main computer, dual desktop, or mirrored. It's a pretty flexible setup.
