I think it depends on the material and task, Steve...
According to Izotope, many of the most sophisticated algorithms, esp the advanced settings in denoise and spectral repair, simply cannot work in plug-form at all. There just isn't enough DSP in current processors for them to work in real time. For reference: I'm running a very tweaky denoise process on some field recordings right now in RX on a Quad G5, 2.5gHz machine, and each 10 minute chunk takes about 30 minutes to complete. This module has realtime settings, and those sound BETTER than Digi's BNR and DNR plugs out of the box, but the non-realtime versions are stunningly good.
For me the biggest issue is workflow, however, and while there are jobs like this that benefit from the extra DSP, most stuff is more mundane, so the eventual plug-based versions will make life a lot easier. I've communicated with the developers about creating faster previews at lower quality, and I hope they give that some thought. The real hang up in the current version is time between previews can be very long, so you forget what's what in between. It's definitely still a 1.0! But it seems stable, and does things others don't.
-d-