my reply might be a little late...
but to me it sounds like a driver and/or resource conflict issue.
since this is a PC, before I break out an O-scope I'd uninstall the drivers for the audio interface, reboot the computer, then reinstall the drivers, and maybe open up windows hardware manager and look for any potential resource conflicts.
If I had a little extra time, just for safe measure, after I uninstalled the drivers, I'd shutdown the computer, remove the PCI audio interface card, go into the bios and have it reset IRQ's for plug and play OS's, boot the computer back up, then shutdown, reinstall the PCI card, go back into the bios and have it reset the IRQ's again (or if I really wanted to take the time to make sure there aren't IRQ conflicts... I'd hardset PCI slot IRQ's... but that would take more time), and reinstall the drivers when the PC booted back up.
Then if I were still having issues, I'd call up the tech support the for manufaturer of the audio interface.
As for checking IDE hard drives... I know some programs that do fairly low level diagnostics (check access/read/write speed and throughput, check for the drive's status via SMART, etc) for SCSI drives but not IDE drives...
just found this
http://en.wikipedia.org/wiki/Self-Monitoring,_Analysis_and_R eporting_Technology
if you're worried about your hard drive this might help you.
-Jeff