For extremely small rooms (V<70m3), especially with some low frequency acoustic treatment, we found “no desk” is a probably best solution, if someone has prerequisites to do that. One of the conditions is to use only mouse/trackball and keyboard for working. Of course, some small DAW controller can be used too.
Idea is to split desk to two halves, and moves (reflecting) surfaces to left and right sides of the chair (above the racks, for example), and miss listener ears. In this case, it is revealed much more high frequency details than with any ordinary desk or/and desk treatments we already know (acoustic foam or cotton felt cover, etc.).
Also, (now) uncovered floor reflections has much smaller bad contribution in overall subjective sound image, because different and longer path, they spoil different frequency range and has much smaller intensity (4-10dB) ... and possibly because we are more naturally immune/adapted to it.
And yes, I agree, this is a story about compromises...
p.s. Also, a big LCD HD TV can be used for computer display, mounted between left and right loudspeaker. This solution solves VGA display diffraction problems too.